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2015
Nov-12
SGLT2 INHIBITOR The New Anti Diabetic Drug
By Dr. Manoj P. Joseph| 0 Comments

Type 2 Diabetes Mellitus accounts for about 95% of all diabetes, typically characterized by insulin resistance and a gradual loss of pancreatic beta cell function (leading to reduction in insulin production).Controlling blood sugar (glucose) levels is the major goal of diabetes treatment.Type 2 diabetes may be managed with dietary changes, weight reduction, exercise and non-insulin medication and insulin. If lifestyle measures fail to achieve adequate blood sugar control, anti-diabetic drugs become necessary. The progressive nature of Type 2 diabetes (the most common variety of diabetes) usually requires combinations of differently acting medication. Now a new option is available called the SGLT 2(sodium-glucose transporter-2) inhibitors. SGLT 2 inhibitors act by eliminating excess glucose in the urine. They do this by inhibiting the SGLT 2 transporter in the kidney, which normally reabsorbs most of the glucose from the kidney. Presence of glucose in urine has long been a feature of poor blood sugar control but SGLT2 inhibitors act to potentate this effect and thereby enhancing elimination of excess glucose through the urine. This drug has some unique properties like weight loss and blood pressure reduction which is not there with other anti-diabetic drugs. The most important feature of this drug is that it doesnt cause hypoglycemia (low blood sugar) which is a nightmare for all the diabetics.

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